先天免疫系统
炎症
细胞生物学
血管生成
血栓调节蛋白
生物
白细胞外渗
免疫学
吞噬作用
癌症研究
免疫系统
凝血酶
血小板
作者
Suzanne S. Bohlson,M. Heather West Greenlee,Sarah Sullivan
出处
期刊:Current Drug Targets
[Bentham Science]
日期:2008-01-29
卷期号:9 (2): 130-138
被引量:60
标识
DOI:10.2174/138945008783502421
摘要
CD93 belongs to a newly described family of transmembrane glycoproteins which also includes endosialin and thrombomodulin. These cell surface proteins are grouped into a family based on similar ectodomain architecture consisting of a C-type lectin-like domain, a series of EGF-like repeats and a highly glycosylated mucin-like domain. However, recent studies suggest overlapping functions in the regulation of processes involving innate immunity and inflammation. CD93 regulates phagocytosis of apoptotic cells in vivo, a function critical to development, tissue repair and maintenance of tissue homeostasis. In addition, in vitro studies have demonstrated a role for CD93 in phagocytosis of antibody and complement opsonized particles and also in leukocyte and endothelial cell adhesion. Analysis of CD93 expression on endothelial cells in the developing mouse embryo correlates with the remodeling of blood vessels suggesting a role for CD93 in regulating angiogenesis, a process tightly linked to acute and chronic inflammation and also required for tumor metastasis. Endosialin has been characterized as a tumor specific antigen and functions in angiogenesis. Thrombomodulin is best characterized as a natural anticoagulant; however, more recent reports have illuminated the importance of thrombomodulin in the regulation of inflammation. This review discusses similarities and differences in the family members, and focuses on known and speculated functions in regulation of innate immunity. Keywords: CD93, thrombomodulin, endosialin, adhesion, phagocytosis, inflammation, angiogenesis, coagulation
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