肌层
表皮生长因子
生长因子
旁分泌信号
血小板源性生长因子受体
转化生长因子
生长因子受体抑制剂
自分泌信号
平滑肌瘤
转化生长因子-α
子宫肌瘤
子宫肌瘤
内分泌学
成纤维细胞生长因子
生物
血管内皮生长因子
癌症研究
血小板衍生生长因子
内科学
作者
Pasquapina Ciarmela,Md. Soriful Islam,Fernando M. Reis,Peter C. Gray,Enrrico Bloise,Felice Petraglia,Wylie Vale,Mario Castellucci
出处
期刊:Human Reproduction Update
[Oxford University Press]
日期:2011-07-25
卷期号:17 (6): 772-790
被引量:158
标识
DOI:10.1093/humupd/dmr031
摘要
Background Growth factors are proteins secreted by a number of cell types that are capable of modulating cellular growth, proliferation and cellular differentiation. It is well accepted that uterine cellular events such as proliferation and differentiation are regulated by sex steroids and their actions in target tissues are mediated by local production of growth factors acting through paracrine and/or autocrine mechanisms. Myometrial mass is ultimately modified in pregnancy as well as in tumour conditions such as leiomyoma and leiomyosarcoma. Leiomyomas, also known as fibroids, are benign tumours of the uterus, considered to be one of the most frequent causes of infertility in reproductive years in women. Methods For this review, we searched the database MEDLINE and Google Scholar for articles with content related to growth factors acting on myometrium; the findings are hereby reviewed and discussed. Results Different growth factors such as epidermal growth factor (EGF), transforming growth factor-α (TGF-α), heparin-binding EGF (HB-EGF), acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), platelet-derived growth factor (PDGF) and TGF-β perform actions in myometrium and in leiomyomas. In addition to these growth factors, activin and myostatin have been recently identified in myometrium and leiomyoma. Conclusions Growth factors play an important role in the mechanisms involved in myometrial patho-physiology.
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