Abstract Anisotropic organic materials are widely studied in photonic and optoelectronic devices. In this work, we show that by mixing two organic materials trans,trans -1,4-distyrylbenzene (DSB) and 1,4-Bis[4-(di-p-tolylamino)styryl]benzene (NDSB), noticeable anisotropy can be introduced in the DSB/NDSB microplates. Inserted in a planar microcavity, particular photonic modes with synthetic Rashba–Dresselhaus coupled bands can be observed with much larger spin splitting (Δ k x = 2.8 μ m −1 ) than other organics or liquid crystal microcavities. Our results offer the study of interesting photon or polariton modes in a synthetic Rashba–Dresselhaus coupled microcavity at room temperature.