作者
Hüseyin Tayran,Elanur Yılmaz,Prabesh Bhattarai,Yuhao Min,Xue Wang,Yiyi Ma,Ni Wang,Inyoung Jeong,Nastasia Nelson,Nada Kassara,Mehmet İlyas Coşacak,Ruya Merve Dogru,Dolly Reyes‐Dumeyer,Jakob Mørkved Stenersen,Joseph S. Reddy,Min Qiao,Delaney Flaherty,Tamil Iniyan Gunasekaran,Zikun Yang,Nathalie Jurisch‐Yaksi,Andrew F. Teich,Takahisa Kanekiyo,Giuseppe Tosto,Badri N. Vardarajan,Özkan İş,Nilüfer Ertekin‐Taner,Richard Mayeux,Çağhan Kızıl
摘要
Genetic variants in ABCA7, an Alzheimer's disease (AD)-associated gene, elevate AD risk, yet its functional relevance to the etiology is unclear. We generated a CRISPR-Cas9-mediated abca7 knockout zebrafish to explore ABCA7's role in AD. Single-cell transcriptomics in heterozygous abca7