亚硝酸盐
一氧化氮
催化作用
化学
亚硝酸盐还原酶
生物物理学
组合化学
生物化学
硝酸盐
生物
有机化学
作者
Yonghai Feng,Yi Yu,Hui Shi,Jiaxiang Bai,L.-S. Wang,T.F. Yang,Lei Liu
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2024-08-30
卷期号:10 (35)
标识
DOI:10.1126/sciadv.adp5935
摘要
The unique bacterial infection microenvironment (IME) usually requires complicated design of nanomaterials to adapt to IME for enhancing antibacterial therapy. Here, an alternative IME adaptative nitrite reductase–mimicking nanozyme is constructed by in situ growth of ultrasmall copper sulfide clusters on the surface of a nanofibrillar lysozyme assembly (NFLA/CuS NHs), which can temporally regulate nitric oxide (NO) gradient concentration to kill bacteria initially and promote tissue regeneration subsequently. Benefiting from a copper nitrite reductase (CuNIR)–inspired structure with CuS cluster as active center and NFLA as skeleton, NFLA/CuS NHs efficiently boost the catalytic reduction of nitrite to NO. The inherent supramolecular fibrillar networks displays excellent bacterial capture capability, facilitating initial high-concentration NO attacks on the bacteria. The subsequent catalytic release of low-concentration NO by NFLA/CuS NHs–mediated nitrite reduction remarkably promotes cell migration and angiogenesis. This work paves the way for dynamically eliminating MDR bacterial infection and promoting tissue regeneration in a simple and smart way through CuNIR-mimicking catalysis.
科研通智能强力驱动
Strongly Powered by AbleSci AI