Prognostic significance of SASP-related gene signature of radiation therapy in head and neck squamous cell carcinoma

头颈部 放射治疗 头颈部鳞状细胞癌 基因签名 肿瘤科 医学 基底细胞 癌症研究 基因 头颈部癌 内科学 病理 生物 基因表达 遗传学 外科
作者
Min Kyeong Lee,Seon Rang Woo,Joo Kyung Noh,Soonki Min,Moonkyoo Kong,Young Chan Lee,Seong‐Gyu Ko,Young‐Gyu Eun
出处
期刊:Molecular Cancer Therapeutics [American Association for Cancer Research]
卷期号:23 (9): 1348-1359 被引量:1
标识
DOI:10.1158/1535-7163.mct-23-0738
摘要

Abstract In this study, we developed and validated the clinical significance of senescence-associated secretory phenotype (SASP)-related gene signature and explored its association with radiation therapy (RT) in patients with head and neck squamous cell carcinoma (HNSCC). First, we searched the three published review literature associated with SASP and selected all 81 genes to develop SASP-related gene signature. Then, 81 SASP-related genes were adapted to gene expression dataset from The Cancer Genome Atlas (TCGA). Patients with HNSCC of TCGA were classified into clusters 1 and 2 via unsupervised clustering according to SASP-related gene signature. Kaplan–Meier plot survival analysis showed that cluster 1 had a poorer prognosis than cluster 2 in 5-year overall survival and recurrence-free survival. Similarly, cluster 1 showed a worse prognosis than cluster 2 in three validation cohorts (E-MTAB-8588, FHCRC, and KHU). Cox proportional hazards regression observed that the SASP-related signature was an independent prognostic factor for patients with HNSCC. We also established a nomogram using a relevant clinical parameter and a risk score. Time-dependent receiver operating characteristic analysis was carried out to assess the accuracy of the prognostic risk model and nomogram. Senescence SASP-related gene signature was associated with the response to RT. Therefore, subsequent, in vitro experiments further validated the association between SASP-related gene signature and RT in HNSCC. In conclusion, we developed a SASP-related gene signature, which could predict survival of patients with HNSCC, and this gene signature provides new clinical evidence for the accurate diagnosis and targeted RT of HNSCC.
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