血栓性微血管病
医学
狼疮性肾炎
抗磷脂综合征
微血管病
肾病
肾
系统性红斑狼疮
发病机制
病理
免疫学
肾脏病理学
内科学
血栓形成
疾病
内分泌学
糖尿病
作者
Larisa Bobrova,N.L. Kozlovskaya
标识
DOI:10.26442/00403660.2024.06.202731
摘要
Lupus nephritis (LN) is one of the most common organ-specific manifestations of systemic lupus erythematosus (SLE). Various clinical signs of LN develop in at least 50% of patients with SLE. In addition to LN, the spectrum of renal lesions associated with SLE also includes vascular pathology. One of the variants of renal microvascular injury is thrombotic microangiopathy (TMA), the mechanisms of which are diverse. The review focuses on the main forms of TMA, including antiphospholipid syndrome and nephropathy associated with antiphospholipid syndrome, TMA caused by complement system regulation disorders and deficiency of ADAMTS13. In most cases, these forms of TMA are combined with LN. However, they may also exist as a single form of kidney damage. This article discusses the TMA pathogenesis, the impact on kidney prognosis, and treatment options.
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