SMAD公司
转化生长因子
特发性肺纤维化
肺纤维化
脱氮酶
泛素
信号转导
发病机制
癌症研究
细胞生物学
生物
免疫学
纤维化
医学
肺
病理
内科学
遗传学
基因
作者
Fang Tang,Hongyan Gong,Tiantian Ke,Wenming Yang,Yuxuan Yang,Zhiyi Liu
出处
期刊:Discovery Medicine
日期:2024-01-01
卷期号:36 (187): 1616-1616
标识
DOI:10.24976/discov.med.202436187.148
摘要
Idiopathic pulmonary fibrosis (IPF) is a long-term, progressive, and irreversible pulmonary interstitial disease. The activation of Smad family member 2 (Smad2) and Smad3 transcription factors by transforming growth factor β-1 (TGF-β1) is a critical event in the pathogenesis of IPF. However, there is still a lack of understanding regarding the molecular mechanisms governing Smad2 and Smad3 proteins. Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays a vital role in regulating protein stability within cells. However, its regulation of the TGF-β signaling pathway and its significance in IPF remain undiscovered. This study aims to clarify the function of USP7 in the TGF-β signaling pathway, while simultaneously exploring the specific molecular mechanisms involved. Additionally, this study seeks to evaluate the therapeutic potential of targeted USP7 inhibitors in IPF, thereby providing novel insights for the diagnosis and management of IPF.
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