脂联素
磷酸盐
化学
内分泌学
受体
内科学
脂联素受体1
生物化学
医学
肥胖
胰岛素抵抗
作者
Jiafan Feng,Xiaochun Ma,Ying Liu,Xiaoliu Shi,Lingbing Jin,Yifei Le,Quan Zhang,Cui Wang
标识
DOI：10.1021/acs.est.4c07051
摘要
Epidemiological evidence links exposure to 2-ethylhexyl diphenyl phosphate (EHDPP) with lipid metabolic disruption, typically attributed to nuclear receptors, while the role of membrane receptors remains underexplored. This study explored the role of adiponectin receptor 1 (AdipoR1) in EHDPP-induced lipid metabolic disturbances. We examined EHDPP's binding affinity and transcriptional impact on AdipoR1. AdipoR1 knockdown (AdipoR1
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