Unlocking the potential of nanomedicine: advances in precision targeting strategies

field of nanomedicine focused on innovative advancements to develop precise targeting strategies and unlock nanomedicine potentialities for precision medicine and relevant pre-clinical and clinical applications for different medical diseases.Nanomedicine is the medical application of nanotechnology and includes the combination of nano-and bio-materials at nanometer scale to manufacture scalable advanced drug delivery systems and medical devices in the perspective to address different pathologies in a complex and heterogeneous scenario [1].The combination of nanomaterials properties, as well as the selectively targeting of microenvironment and tissue through physiological and pathological mechanisms, can modulate the micro-and macro-environments of the diseases in patients affected by rare and clinically relevant pathologies; thus providing specific properties for tailoring precision medicine, and boosting the application for many diseases with suitable therapeutic options and benefits for the patients [2].The chemical, physical and biological targeting of nanomedicine unlock their potentiality and led to their development as diagnostic/medical devices, contrast agents, analytical tools, physical therapeutic agents, and drug delivery systems [3][4][5].This special issue seeks to deliver a valuable set of research tools and clinically useful devices and may foster the translation of nanomedicine from bench to bed side in the perspective of personalized therapy towards a reliable pre-clinical and clinical assessment [6][7][8][9][10].In this scenario, nanoparticles, with different compositions and interface properties, may foster the translation of basic science in personalized nanomedicines for different therapeutic application and provide a significant impact in therapy and treatment of metabolic and non-metabolic diseases.This special issue on "Unlocking the potential of nanomedicine: advances in precision targeting strategies" addresses a cutting-edge and multidisciplinary field of nanomedicine.This special issue is dedicated to nanomedicine and aimed to combine the expertise of a large number of scientists worldwide with extensive experience in nanomedicine, but also to discuss how fostering basic science into translational and personalized medicine for drug delivery applications.This can be achieved by a cutting-edge and multidisciplinary