脂质代谢
葡甘露聚糖
内分泌学
肥胖
化学
内科学
胰岛素抵抗
新陈代谢
碳水化合物代谢
食欲
食品科学
生物
医学
作者
Si-Jun Zhu,Jing Wang,Pengkui Xia,Sha Li,Xiaogang Wang,Kaikai Li,Bin Li,Jing Li
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2024-01-01
摘要
Konjac glucomannan (KGM) is a dietary fiber supplement that exhibits multiple biological activities, including weight control as well as regulation of glucose and lipid metabolism. Currently, KGM intake patterns in practical applications include KGM sol, thermal irreversible gel, and frozen thermal irreversible gel. In this study, four intake patterns of KGM, namely KGM sol (KS), deacetylated KGM (DK), KGM gel (KG), and frozen KGM gel (FKG), were used as materials to explore the effects of different KGM intake patterns on glucose and lipid metabolism and intestinal flora in obese mice induced by a high fat diet under the same dose. The results showed that any type of KGM intake could reduce body weight, fat mass, lipid levels, and insulin resistance in obese mice, and alleviate liver damage and inflammation caused by obesity. However, KS has the most significant effect on controlling blood glucose and blood lipid in obese mice. Additionally, it was found that KS, DK, KG and FKG can increase the α-diversity of intestinal microflora in high-fat mice and improve the microflora disorder in high-fat mice. Finally, KS may increase the levels of fasting appetite hormones GLP-1 and PYY in mice, up-regulate the expression of
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