糖原发生
生物
糖原
肝细胞
细胞生物学
内科学
糖原合酶
内分泌学
生物化学
体外
医学
作者
Xianghong Xie,Mingyue Gao,H Wang,Minglong Zhang,Wei Zhao,C W Li,Weihong Zhang,Jiahui Yang,Yinliang Zhang,E CHEN,Yanfang Guo,Zeyu Guo,Ebenezeri Erasto Ngowi,Xiaoman Wang,Yinghan Zhu,Yiting Wang,Xiaolu Li,Hong Yao,Yan Li,Fude Fang,M. Li,Aijun Qiao,Xiaojun Liu
标识
DOI:10.1096/fj.202401064r
摘要
Long noncoding RNAs (lncRNAs) are strongly associated with glucose homeostasis, but their roles remain largely unknown. In this study, the potential role of lncRNA-Snhg3 in glucose metabolism was evaluated both in vitro and in vivo. Here, we found a positive relationship between Snhg3 and hepatic glycogenesis. Glucose tolerance improved in hepatocyte-specific Snhg3 knock-in (Snhg3-HKI) mice, while it worsened in hepatocyte-specific Snhg3 knockout (Snhg3-HKO) mice. Furthermore, hepatic glycogenesis had shown remarkable increase in Snhg3-HKI mice and reduction in Snhg3-HKO mice, respectively. Mechanistically, Snhg3 increased mRNA and protein expression levels of PPP1R3B through inducing chromatin remodeling and promoting the phosphorylation of protein kinase B. Collectively, these results suggested that lncRNA-Snhg3 plays a critical role in hepatic glycogenesis.
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