特应性皮炎
免疫学
过敏
口服免疫疗法
免疫疗法
卵清蛋白
肠道菌群
脱敏(药物)
生物
食物过敏
免疫系统
生物化学
受体
作者
Xiaochun Liu,Beilei Xu,Xiaoqiang Xu,Zhifeng Wang,Yang Luo,Yingxia Gao,Shiqi Ling,Ao Wang,Yuan Zhou,Xiaokai Wang,Sean X. Leng,Wei Li,Xu Yao
标识
DOI:10.1016/j.xcrm.2023.101340
摘要
Allergen-specific immunotherapy (AIT) has shown beneficial effects against atopic dermatitis (AD); however, the mechanisms and parameters underlying the efficacy of AIT remain unclear. Here, we report that the community structure and function of the oral and gut microbiota are changed in patients with AD undergoing AIT. Transplantation of fecal microbiota from patients who respond well to AIT improves AD-like dermatitis in mice. The abundance of Brevundimonas vesicularis in the gut of AD patients has been found to be positively correlated with disease severity and is decreased following AIT. Furthermore, we find that B. vesicularis from the oral cavity might ectopically colonize the gut of AD patients. In AD model mice, meanwhile, B. vesicularis promotes the skewing of the Treg/Th17 balance toward Th17 polarization and attenuates the efficacy of ovalbumin-specific immunotherapy. Our findings provide potential strategies for the optimization of AIT for AD via the modulation of the gut microbiota.
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