Predicting heart failure: The promise of proteomics

European Journal of Heart FailureVolume 26, Issue 1 p. 103-106 Invited Editorial Predicting heart failure: The promise of proteomics Andreas P. Kalogeropoulos, Corresponding Author Andreas P. Kalogeropoulos [email protected] Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY, USA Corresponding author. Stony Brook University Medical Center, 101 Nicolls Road, Health Sciences Center, T-16-080, Stony Brook, NY 11794-8167, USA. Tel: +1 631 638-0081, Fax: +1 631 444-1054, Email: [email protected]Search for more papers by this authorKristine H. Jang, Kristine H. Jang Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY, USASearch for more papers by this authorMichael E. Hall, Michael E. Hall Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USASearch for more papers by this author Andreas P. Kalogeropoulos, Corresponding Author Andreas P. Kalogeropoulos [email protected] Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY, USA Corresponding author. Stony Brook University Medical Center, 101 Nicolls Road, Health Sciences Center, T-16-080, Stony Brook, NY 11794-8167, USA. Tel: +1 631 638-0081, Fax: +1 631 444-1054, Email: [email protected]Search for more papers by this authorKristine H. Jang, Kristine H. Jang Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY, USASearch for more papers by this authorMichael E. Hall, Michael E. Hall Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USASearch for more papers by this author First published: 08 January 2024 https://doi.org/10.1002/ejhf.3126 The opinions expressed in this article are not necessarily those of the Editors of the European Journal of Heart Failure or of the European Society of Cardiology. doi: 10.1002/ejhf.3086. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1Emilsson V, Jonsson BG, Austin TR, Gudmundsdottir V, Axelsson GT, Frick EA, et al. Proteomic prediction of incident heart failure and its main subtypes. Eur J Heart Fail 2024; 26: 87–102. https://doi.org/10.1002/ejhf.3086 10.1002/ejhf.3086 CASPubMedGoogle Scholar 2Stenemo M, Nowak C, Byberg L, Sundstrom J, Giedraitis V, Lind L, et al. Circulating proteins as predictors of incident heart failure in the elderly. Eur J Heart Fail 2018; 20: 55–62. https://doi.org/10.1002/ejhf.980 10.1002/ejhf.980 CASPubMedWeb of Science®Google Scholar 3Ferreira JP, Verdonschot J, Collier T, Wang P, Pizard A, Bar C, et al. Proteomic bioprofiles and mechanistic pathways of progression to heart failure. Circ Heart Fail 2019; 12:e005897. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005897 10.1161/CIRCHEARTFAILURE.118.005897 CASPubMedWeb of Science®Google Scholar 4Nayor M, Short MI, Rasheed H, Lin H, Jonasson C, Yang Q, et al. Aptamer-based proteomic platform identifies novel protein predictors of incident heart failure and echocardiographic traits. Circ Heart Fail 2020; 13:e006749. https://doi.org/10.1161/CIRCHEARTFAILURE.119.006749 10.1161/CIRCHEARTFAILURE.119.006749 CASPubMedWeb of Science®Google Scholar 5Lind L, Zanetti D, Ingelsson M, Gustafsson S, Arnlov J, Assimes TL. Large-scale plasma protein profiling of incident myocardial infarction, ischemic stroke, and heart failure. J Am Heart Assoc 2021; 10:e023330. https://doi.org/10.1161/JAHA.121.023330 10.1161/JAHA.121.023330 PubMedGoogle Scholar 6Egerstedt A, Berntsson J, Smith ML, Gidlof O, Nilsson R, Benson M, et al. Profiling of the plasma proteome across different stages of human heart failure. Nat Commun 2019; 10: 5830. https://doi.org/10.1038/s41467-019-13306-y 10.1038/s41467-019-13306-y CASPubMedWeb of Science®Google Scholar 7Donnarumma E, Bhushan S, Bradley JM, Otsuka H, Donnelly EL, Lefer DJ, et al. Nitrite therapy ameliorates myocardial dysfunction via H2S and nuclear factor-erythroid 2-related factor 2 (Nrf2)-dependent signaling in chronic heart failure. J Am Heart Assoc 2016; 5:e003551. https://doi.org/10.1161/JAHA.116.003551 10.1161/JAHA.116.003551 PubMedWeb of Science®Google Scholar 8Henique C, Bollee G, Lenoir O, Dhaun N, Camus M, Chipont A, et al. Nuclear factor erythroid 2-related factor 2 drives podocyte-specific expression of peroxisome proliferator-activated receptor γ essential for resistance to crescentic GN. J Am Soc Nephrol 2016; 27: 172–188. https://doi.org/10.1681/ASN.2014111080 10.1681/ASN.2014111080 CASPubMedWeb of Science®Google Scholar 9Ren S, Bian Y, Hou Y, Wang Z, Zuo Z, Liu Z, et al. The roles of NFE2L1 in adipocytes: Structural and mechanistic insight from cell and mouse models. Redox Biol 2021; 44:102015. https://doi.org/10.1016/j.redox.2021.102015 10.1016/j.redox.2021.102015 CASPubMedWeb of Science®Google Scholar 10Henry A, Gordillo-Maranon M, Finan C, Schmidt AF, Ferreira JP, Karra R, et al. Therapeutic targets for heart failure identified using proteomics and Mendelian randomization. Circulation 2022; 145: 1205–1217. https://doi.org/10.1161/CIRCULATIONAHA.121.056663 10.1161/CIRCULATIONAHA.121.056663 CASPubMedWeb of Science®Google Scholar 11Takvorian KS, Wang D, Courchesne P, Vasan RS, Benjamin EJ, Cheng S, et al. The association of protein biomarkers with incident heart failure with preserved and reduced ejection fraction. Circ Heart Fail 2023; 16:e009446. https://doi.org/10.1161/CIRCHEARTFAILURE.121.009446 10.1161/CIRCHEARTFAILURE.121.009446 CASPubMedWeb of Science®Google Scholar 12Petersen TB, de Bakker M, Asselbergs FW, Harakalova M, Akkerhuis KM, Brugts JJ, et al. HFrEF subphenotypes based on 4210 repeatedly measured circulating proteins are driven by different biological mechanisms. EBioMedicine 2023; 93:104655. https://doi.org/10.1016/j.ebiom.2023.104655 10.1016/j.ebiom.2023.104655 CASPubMedWeb of Science®Google Scholar 13Muntner P, Hardy ST, Fine LJ, Jaeger BC, Wozniak G, Levitan EB, et al. Trends in blood pressure control among US adults with hypertension, 1999-2000 to 2017-2018. JAMA 2020; 324: 1190–1200. https://doi.org/10.1001/jama.2020.14545 10.1001/jama.2020.14545 PubMedWeb of Science®Google Scholar Volume26, Issue1January 2024Pages 103-106 ReferencesRelatedInformation