斑马鱼
牙周炎
化学
体内
一氧化氮
荧光
唾液
生物物理学
纳米技术
炎症
体外
细胞生物学
生物化学
免疫学
生物
材料科学
医学
物理
有机化学
内科学
基因
生物技术
量子力学
作者
Yibin Zhang,Shaocai Wang,Yu Sun,Hanbo Xu,Zihan Xu,Liang Xin,Jianguang Yang,Weiyi Song,Ming‐Hui Chen,Mingxi Fang
标识
DOI:10.1016/j.bioorg.2023.107014
摘要
Many pathological processes include nitric oxide (NO), a signaling transduction molecule. Tumors, cardiovascular, cerebrovascular, neurodegenerative, and other illnesses are linked to abnormal NO levels. Thus, evaluating NO levels in vitro and in vivo is crucial for studying chemical biology process of associated disorders. This work devised and manufactured a coumarin-based fluorescent probe ZPS-NO to detect nitric oxide (NO). The reaction between ZPS-NO and NO produced a highly selective and sensitive optical response that caused a powerful fluorescence "turn-on" effect with a ultra-low NO detection limit of 14.5 nM. Furthermore, the probe was applied to sense and image NO in living cells and inflammatory model of zebrafish, as well as to detect NO in periodontitis patients' saliva samples. We anticipate that probe ZPS-NO will serve as a practical and effective tool for assessing the interactions and evaluation of periodontitis development.
科研通智能强力驱动
Strongly Powered by AbleSci AI