神经病理性疼痛
麻醉
医学
睡眠(系统调用)
非快速眼动睡眠
睡眠障碍
脑电图
失眠症
精神科
计算机科学
操作系统
作者
Anh Ho,Sung‐Jun Lee,Victor James Drew,Joon Pyo Jung,Jiseung Kang,Tae Kim,C.C. Cheong
摘要
Summary The association between sleep and pain has been investigated widely. However, inconsistent results from animal studies compared with human data show the need for a validated animal model in the sleep–pain association field. Our study aims to validate common neuropathic pain models as a tool for evaluating the sleep–pain association. Electrodes electroencephalogram (EEG) and electromyogram (EMG) were surgically implanted to measure sleep. The von Frey test was used to measure pain sensitivity. Following the baseline data acquisition, two pain‐modelling procedures were performed: sciatic nerve crush injury (SCI) and common peroneal nerve ligation (CPL). Post‐injury measurements were performed on days 1, 5, 10, and 15 post‐surgery. The results presented decreased paw withdrawal thresholds and reduced NREM sleep duration in both models on the first post‐surgery day. In the SCI model, NREM sleep duration was negatively correlated with paw withdrawal thresholds ( p = 0.0466), but not in the CPL model. Wake alpha and theta EEG powers were also correlated with the pain threshold. The results confirm that the SCI model shows disturbed sleep patterns associated with increased pain sensitivity, suggesting it is a reliable tool for investigating sleep disturbances associated with neuropathic pain.
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