A Novel Food Bore Protein Hydrogel with Silver Ions for Promoting Burn Wound Healing

Abstract Hydrogels have emerged as a promising option for treating local scald wounds due to their unique physical and chemical properties. This study aims to evaluate the efficacy of ovalbumin/gelatin composite hydrogels in repairing deep II‐degree scald wounds using a mouse dorsal skin model. Trauma tissues collected at various time points are analyzed for total protein content, hydroxyproline content, histological features, and expression of relevant markers. The results reveal that the hydrogel accelerates the healing process of scalded wounds, which is 17.27% higher than the control group. The hydrogel treatment also effectively prevents wound enlargement and redness of the edges caused by infection during the initial stage of scalding. The total protein and hydroxyproline content of the treated wounds are significantly elevated. Additionally, the hydrogel up‐regulates the expression of VEGF (a crucial angiogenic factor) and down‐regulates CD68 (a macrophage marker). In summary, this study provides valuable insights into the potential of multifunctional protein‐based hydrogels in wound healing.