机制(生物学)
骨质疏松症
RNA结合蛋白
骨重建
核糖核酸
疾病
骨病
生物信息学
医学
生物
内科学
内分泌学
遗传学
认识论
哲学
基因
作者
Jiaqiang Wu,Liyan Niu,Kangping Yang,Jiangnan Xu,Deju Zhang,Jitao Ling,Panpan Xia,Yuting Wu,Xiao Liu,Jianping Liu,Jing Zhang,Peng Yu
标识
DOI:10.1016/j.arr.2024.102234
摘要
Osteoporosis is a prevalent chronic metabolic bone disease that poses a significant risk of fractures or mortality in elderly individuals. Its pathophysiological basis is often attributed to postmenopausal estrogen deficiency and natural aging, making the progression of primary osteoporosis among elderly people, especially older women, seemingly inevitable. The treatment and prevention of osteoporosis progression have been extensively discussed. Recently, as researchers delve deeper into the molecular biological mechanisms of bone remodeling, they have come to realize the crucial role of posttranscriptional gene control in bone metabolism homeostasis. RNA-binding proteins, as essential actors in posttranscriptional activities, may exert influence on osteoporosis progression by regulating the RNA life cycle. This review compiles recent findings on the involvement of RNA-binding proteins in abnormal bone metabolism in osteoporosis and describes the impact of some key RNA-binding proteins on bone metabolism regulation. Additionally, we explore the potential and rationale for modulating RNA-binding proteins as a means of treating osteoporosis, with an overview of drugs that target these proteins.
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