亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Influence of quercetin on amiodarone pharmacokinetics and biodistribution in rats.

最大值 药代动力学 药理学 生物利用度 槲皮素 CYP3A4型 医学 加药 化学 治疗指标 药品 细胞色素P450 抗氧化剂 内科学 新陈代谢 生物化学
作者
Ejaz Ahmad,Muhammad Jahangir,Nadeem Irfan Bukhari,Josephine Khan,Asma Sarwar,Tariq Aziz,Ghulam Nabi,Mohammed Alharbi,H A Thamer,Abdullah F. Alasmari
出处
期刊:PubMed 卷期号:27 (23): 11211-11221 被引量:3
标识
DOI:10.26355/eurrev_202312_34561
摘要

Amiodarone (AMD), a drug of choice to treat cardiac arrhythmias, has a narrow therapeutic index (NTI). It inhibits CYP3A4, CYP2C9, and CYP2D6 enzymes. Quercetin (QUE), a pharmacologically important bioflavonoid in vegetables and fruits, is important in treating cardiovascular comorbidities. QUE alters the bioavailability of drugs used concurrently by dual inhibition of P-glycoproteins (P-gp) and cytochrome (CYP) enzyme systems. The current study aimed to investigate the pre-treatment and co-administration effect of QUE on AMD pharmacokinetics in rats.Two separate animal trials (I and II) were planned to probe the effect of QUE on AMD pharmacokinetics by following previously cited studies. The pre-treatment group received oral doses of QUE for 14 days, and a single dose of AMD on the 15th day. Rats were administered single doses of QUE (20 mg/kg) and AMD (50 mg/kg) concurrently in a carboxymethylcellulose (CMC) in the co-administration study. Blood was collected at pre-determined time points. AMD was quantified by HPLC, and data was analyzed by PK solver software.In the pre-treated group, peak plasma concentration (Cmax) and area under the curve (AUC0-∞) of AMD were increased by 45.52% and 13.70%, respectively, while time to achieve maximum concentration (tmax), half-life (t1/2) and clearance (CL) were declined by 35.72%, 16.75%, and 11.0% respectively compared to the control. In the co-administered group, compared to controls, Cmax and AUC0-∞ were elevated to 12.90% and 7.80%, respectively, while tmax, t1/2, and CL declined by 16.70%, 2.35%, and 13.40%. Further, AMD was increased in lung tissue of both treated groups, relative to the respective controls.A notable pharmacokinetic drug interaction between QUE and AMD was observed in rats and warrants possible drug interaction study in humans, suggesting AMD dose adjustment specifically in patients with arrhythmia having a pre-treatment history and simultaneous administration of QUE-containing products.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
婼汐完成签到 ,获得积分10
刚刚
活力半凡完成签到,获得积分10
9秒前
Cathy完成签到,获得积分10
18秒前
科研通AI2S应助科研通管家采纳,获得10
20秒前
怕孤单的思雁完成签到,获得积分10
1分钟前
闫雪发布了新的文献求助10
1分钟前
gszy1975完成签到,获得积分10
1分钟前
TiYooY完成签到,获得积分10
1分钟前
Benhnhk21发布了新的文献求助10
1分钟前
2分钟前
科研通AI2S应助科研通管家采纳,获得50
2分钟前
5433完成签到 ,获得积分10
3分钟前
jiangjiang完成签到 ,获得积分10
3分钟前
吱吱草莓派完成签到 ,获得积分10
3分钟前
4分钟前
小二郎应助科研通管家采纳,获得10
4分钟前
4分钟前
4分钟前
宝贝丫头完成签到 ,获得积分10
4分钟前
英姑应助背后的鞋垫采纳,获得10
4分钟前
桐桐应助Benhnhk21采纳,获得10
4分钟前
Dave发布了新的文献求助10
5分钟前
科研通AI2S应助科研通管家采纳,获得10
6分钟前
Aaron完成签到 ,获得积分0
6分钟前
6分钟前
8分钟前
Liufgui应助Dave采纳,获得10
9分钟前
Benhnhk21发布了新的文献求助10
9分钟前
yydragen应助yyds采纳,获得10
9分钟前
Hisam完成签到,获得积分10
9分钟前
lhy完成签到,获得积分10
9分钟前
lhy发布了新的文献求助10
9分钟前
9分钟前
积极的台灯应助Benhnhk21采纳,获得10
9分钟前
Hisam发布了新的文献求助10
9分钟前
yyds完成签到,获得积分0
9分钟前
科研通AI2S应助科研通管家采纳,获得10
10分钟前
木木完成签到 ,获得积分10
10分钟前
10分钟前
董可以发布了新的文献求助10
10分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990298
求助须知:如何正确求助?哪些是违规求助? 3532146
关于积分的说明 11256481
捐赠科研通 3271042
什么是DOI,文献DOI怎么找? 1805197
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234