Redox-regulating nanotherapeutics potentiating ferroptosis-driven cancer treatment

Ferroptosis has garnered considerable attention benefiting from its remarkable potential in fighting malignant tumors. Its occurrence largely relies the overwhelming accumulation of lethal lipid peroxides accompanied by redox dyshomeostasis and irreversible oxidative damage to tumor cells. Given that intracellular redox homeostasis is closely associated with ferroptosis, numerous redox homeostasis-modulating nanomedicines have been developed for ferroptosis-driven antitumor therapy in recent years. As a new biomedical research hotspot, it's timely to outline the latest advances in redox-regulating nanotherapeutics potentiating ferroptosis-driven cancer treatment. Herein, we aim to present the emerging breakthroughs in this exciting field at the intersection of redox homeostasis, ferroptosis, nanotechnology, and cancer treatments. This review focuses on several ferroptosis-related redox homeostasis regulation strategies, including amplification of reactive oxygen species generation, suppression of antioxidant defense systems, bidirectional modulation of redox homeostasis, and ferroptosis-based multimodal modalities. Finally, we highlight the rationale, superiorities, and challenges of redox dyshomeostasis-evoked ferroptosis anticancer nanotherapeutics.