Recurrent Hospitalizations and Response to Vericiguat in Heart Failure and Reduced Ejection Fraction

射血分数 利钠肽 心力衰竭 心脏病学 临床终点 内科学 安慰剂 医学 子群分析 置信区间 随机对照试验 病理 替代医学
作者
Robert J. Mentz,Amanda Stebbins,Javed Butler,Chern‐En Chiang,Justin A. Ezekowitz,Adrian F. Hernandez,Robert Hilkert,Carolyn S.P. Lam,Kenneth McDonald,Christopher M. O’Connor,Burkert Pieske,Piotr Ponikowski,Lothar Roessig,Nancy K. Sweitzer,Adriaan A. Voors,Kevin J. Anstrom,Paul W. Armstrong
出处
期刊:Jacc-Heart Failure [Elsevier BV]
卷期号:12 (5): 839-846 被引量:4
标识
DOI:10.1016/j.jchf.2023.12.005
摘要

In VICTORIA (Vericiguat Global Study in Subjects With Heart Failure With Reduced Ejection Fraction), vericiguat compared with placebo reduced cardiovascular death or heart failure (HF) hospitalization in patients with HF with reduced ejection fraction. This study explored the association between vericiguat and recurrent hospitalizations and subsequent mortality after HF hospitalization. The treatment effect of vericiguat on the burden of HF hospitalizations was evaluated by assessing total HF hospitalization and cardiovascular death in the overall trial and based on baseline N-terminal pro–B-type natriuretic peptide levels with and without adjustment for VICTORIA model covariates (ie, baseline variables associated with the primary endpoint) assessed via the Andersen-Gill method. Associations between vericiguat and recurrent hospitalization and mortality adjusted for VICTORIA model covariates are reported. There were 1,222 total HF hospitalizations and cardiovascular deaths among 2,526 patients in the vericiguat group and 1,336 total events among 2,524 patients in the placebo group (unadjusted HR: 0.89 [95% CI: 0.81-0.97] and adjusted HR: 0.92 [95% CI: 0.84-1.01]). In the subgroup with N-terminal pro–B-type natriuretic peptide levels ≤2,816 pg/mL (ie, Q1 and Q2; median or below), there was a suggestion of a benefit with vericiguat (adjusted HRs of 0.80 [95% CI: 0.64-1.01] and 0.77 [95% CI: 0.62-0.94], respectively) compared with those above this value (adjusted HRs of 1.12 [95% CI: 0.93-1.34] and 0.87 [95% CI: 0.74-1.04] for Q3 and Q4). There was no significant difference in treatment effect between patients with vs without an HF hospitalization. After HF hospitalization, the all-cause mortality rate (events per 100 patient-years) was 48.6 for vericiguat and 44.1 for placebo. Additional investigation of the association between vericiguat and cardiovascular death and total HF hospitalizations by recurrent event analysis did not show a statistically significant reduction in events. Mortality was high after HF hospitalization, emphasizing the need for further therapies to reduce morbidity and mortality. (Vericiguat Global Study in Subjects With Heart Failure With Reduced Ejection Fraction [VICTORIA]; NCT02861534)
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
琳琅发布了新的文献求助10
3秒前
xue完成签到 ,获得积分10
4秒前
liars完成签到 ,获得积分10
4秒前
搞怪人雄完成签到,获得积分10
7秒前
落后的夜阑完成签到,获得积分10
7秒前
大橙子发布了新的文献求助10
10秒前
彪行天下完成签到,获得积分10
15秒前
danli完成签到 ,获得积分10
16秒前
guangyu完成签到,获得积分10
18秒前
学术老6完成签到,获得积分10
19秒前
c123完成签到 ,获得积分10
21秒前
恐怖稽器人完成签到,获得积分10
21秒前
WXR完成签到,获得积分10
22秒前
科研小白完成签到,获得积分10
22秒前
23秒前
可爱丸子完成签到,获得积分10
23秒前
皮汤汤完成签到 ,获得积分10
24秒前
JXDYYZK完成签到,获得积分10
25秒前
SYLH应助lu采纳,获得10
25秒前
Servant2023完成签到,获得积分10
25秒前
鸽子的迷信完成签到,获得积分10
27秒前
nine2652完成签到 ,获得积分10
28秒前
烂漫的睫毛完成签到 ,获得积分10
30秒前
量子星尘发布了新的文献求助10
30秒前
陈老太完成签到 ,获得积分10
31秒前
宇宇宇c完成签到,获得积分10
32秒前
zxt完成签到,获得积分10
33秒前
大橙子发布了新的文献求助10
36秒前
聪明静柏完成签到 ,获得积分10
38秒前
kimiwanano完成签到,获得积分10
40秒前
lu完成签到,获得积分10
41秒前
Profeto应助齐嫒琳采纳,获得10
42秒前
43秒前
情怀应助科研通管家采纳,获得10
44秒前
从来都不会放弃zr完成签到,获得积分10
48秒前
1459完成签到,获得积分10
50秒前
行者+完成签到,获得积分10
50秒前
GongSyi完成签到 ,获得积分10
51秒前
Boris完成签到 ,获得积分10
53秒前
哭泣笑柳完成签到,获得积分10
53秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022