植物化学
查尔酮
根茎
生物
化学分类学
立体化学
圆二色性
传统医学
植物
化学
生物化学
分类学(生物学)
医学
作者
Jiang Wan,Guangyao Mei,Jun-Xia Ma,Ze‐Yu Zhao,Can Wang,Ziping Zhu,Junmin Li,Jin‐Feng Hu
标识
DOI:10.1016/j.bse.2023.104773
摘要
A phytochemical investigation of the rhizomes of Polygonatum cyrtonema, a traditional Chinese medicine and healthy food named "Huang-jing" (Polygonati Rhizoma), led to the isolation of 22 phenolic derivatives including an undescribed (1) and nine (2–10) known C-methylated homoisoflavanones, two common homoisoflavanones (11, 12), four flavanones (13–16), one chalcone (17), and five octopamine derivatives (18–22). The structure of compound 1 was established mainly by spectroscopic methods, including 1D-/2D-NMR and electronic circular dichroism (ECD). The known compounds were identified by comparing the observed and reported physicochemical properties and spectroscopic data published in the literature. Polygonatone H (8) and 5,7,2′-trihydroxy-4′-methoxy-6,8-dimethyl-homoisoflavanone (9) exhibited significant cytotoxic effects against four human cancer cell lines (HCT-116, AGS, U-87 MG, and PC-12) with IC50 values ranging from 2.2 to 9.8 μM. Furthermore, the chemotaxonomic significance of the isolated C-methylated homoisoflavanones was briefly discussed.
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