Self‐Tandem Bio‐Heterojunctions Empower Orthopedic Implants with Amplified Chemo‐Photodynamic Anti‐Pathogenic Therapy and Boosted Diabetic Osseointegration

Abstract Hyperglycemic microenvironment in diabetes mellitus inevitably stalls the normal orchestrated course of bone regeneration and encourages pathogenic multiplication. Photodynamic therapy (PDT) and chemo‐dynamic therapy (CDT) are extensively harnessed to combat pathogens, yet deep‐seated diabetic bone defect has difficulty in supplying sufficient oxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ) stocks, resulting in inferior therapeutic efficiency. To address the tough plaguing, the self‐tandem bio‐heterojunctions (bio‐HJs) consisting of molybdenum disulfide (MoS 2 ), graphene oxide (GO), and glucose oxidase (GOx) are constructed on orthopedic polyetheretherketone (PEEK) implants (SP‐Mo/G@GOx) for amplified chemo‐photodynamic anti‐pathogenic therapy and boosted osseointegration in the deep‐seated diabetic micromilieu. In this system, GOx exhausts glucose to generate H 2 O 2 , which provides an abundant stock for CDT. Besides, the bio‐HJs produce hyperthermia upon near‐infrared light (NIR) to accelerate the dynamic process, which amplifies the antibacterial potency of PDT by promoting the vast yield of singlet oxygen ( 1 O 2 ) in a self‐tandem manner. More importantly, in vivo and in vitro assays demonstrate that the engineered implants exert a captivated bactericidal ability and significantly boost osseointegration in an infectious diabetic bone defect model. As envisaged, this study furnishes a novel tactic to arm orthopedic implants with self‐tandem capability for the remedy of infectious diabetic bone defects.