材料科学
过氧化氢
激进的
纳米颗粒
奥氏体
化学工程
自由基加成
复合材料
纳米技术
高分子化学
有机化学
微观结构
化学
工程类
作者
Chen Yang,Yunzhi Song,Chaojie Tang,Hong Yang,Wei Wu,Sen Yang,Zhiguo Zhou
标识
DOI:10.1016/j.jmst.2023.07.002
摘要
It is desirable to develop a free radical generator that is neither dependent on hydrogen peroxide nor external stimuli-triggered to achieve effective tumor treatment. Herein, the free radical generator MNPs-mCPBA was constructed with Zn0.4Co0.6Fe2O4@Zn0.4Mn0.6Fe2O4 nanoparticles (MNPs) and 3-chloroperbenzoic acid (mCPBA). We believe that the iron (II) on the surface of MNPs-mCPBA maybe represent high reactive activity and promote the generation of a large number of organic free radicals (C6H4ClCOOO⋅) in an acidic tumor microenvironment, which realizes the acid-dependent tumor treatment strategy independent on the H2O2 level in tumors. In addition, the generated organic free radicals (C6H4ClCOOO⋅) effectively induced immunogenic cell death (ICD) and increased T cell infiltration. Under the synergetic treatment with an anti-PD-L1 antibody (α-PD-L1), a favorable anti-tumor effect was achieved.
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