癫痫
谷氨酸受体
抗惊厥药
氧化应激
病理生理学
药理学
益生菌
谷氨酸
γ-氨基丁酸
惊厥
海马结构
癫痫发作
医学
内科学
化学
生物
生物化学
氨基酸
受体
精神科
遗传学
细菌
作者
Arzuhan ÇETİNDAĞ ÇİLTAŞ,Cemal Erdem Toy,Handan Güneş,Mustafa Yaprak
标识
DOI:10.1016/j.eplepsyres.2023.107190
摘要
Studies conducted in recent years have indicated a relationship between epilepsy and gut microbiota. Ion channels, excitatory/inhibitory balance and regulatory systems play a role in the pathophysiology of epilepsy. In addition, gut dysbiosis is also involved in the pathophysiology of epilepsy. This research investigated the impacts of probiotic mixture on epileptic seizures, Gamma aminobutyric acid (GABA), glutamate, and TAS and TOS levels in hippocampal tissue in the PTZ-induced acute seizure model in rats. Four groups were formed with male Wistar albino rats. The first and second groups were given 1 ml/day saline solution, and the other groups were given 0.05 mg/1 ml/day vehicle or 109cfu/1 ml/day probiotic supplementation, respectively via gavage for 21 days. A single-dose PTZ (45 mg/kg) was administered to induce seizure. The stages of seizure were analyzed according to the Racine scale. While ELISA was used to determine GABA and glutamate levels in the hippocampus, an automated colorimetric method was utilized to measure oxidant/antioxidant biomarkers. It was found that by delaying the first myoclonic jerk (FMJ), and the onset of the generalized tonic-clonic seizures, the probiotic mixture demonstrated anticonvulsant effects against seizures. The probiotic mixture was found to increase the inhibitory neurotransmitter GABA. It was also found to decrease TOS levels and increase TAS concentration. The findings of this study showed that probiotic mixture reduced oxidative stress with its positive effects against PTZ-induced epileptic seizures. Further studies are needed to reveal potentially related mechanisms.
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