低语长廊波浪
生物传感器
谐振器
纳米技术
计算机科学
模式
声传感器
材料科学
物理
光电子学
声学
社会学
社会科学
作者
Médéric Loyez,Maxwell Adolphson,Jie Liao,Lan Yang
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2023-06-30
卷期号:8 (7): 2440-2470
被引量:19
标识
DOI:10.1021/acssensors.2c02876
摘要
Optical biosensors are frontrunners for the rapid and real-time detection of analytes, particularly for low concentrations. Among them, whispering gallery mode (WGM) resonators have recently attracted a growing focus due to their robust optomechanical features and high sensitivity, measuring down to single binding events in small volumes. In this review, we provide a broad overview of WGM sensors along with critical advice and additional "tips and tricks" to make them more accessible to both biochemical and optical communities. Their structures, fabrication methods, materials, and surface functionalization chemistries are discussed. We propose this reflection under a pedagogical approach to describe and explain these biochemical sensors with a particular focus on the most recent achievements in the field. In addition to highlighting the advantages of WGM sensors, we also discuss and suggest strategies to overcome their current limitations, leaving room for further development as practical tools in various applications. We aim to provide new insights and combine different knowledge and perspectives to advance the development of the next generation of WGM biosensors. With their unique advantages and compatibility with different sensing modalities, these biosensors have the potential to become major game changers for biomedical and environmental monitoring, among many other relevant target applications.
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