A Pilot Study of Near-Infrared Light Treatment for Alzheimer’s Disease

医学 不利影响 阿尔茨海默病 临床试验 内科学 认知 疾病 精神科
作者
Liang Chen,Jun Xue,Qianhua Zhao,Xiaoniu Liang,Li Zheng,Zhen Fan,Ibrahima Sory Jnr Souare,Yuanzhen Suo,Xunbin Wei,Ding Ding,Ying Mao
出处
期刊:Journal of Alzheimer's Disease [IOS Press]
卷期号:91 (1): 191-201 被引量:4
标识
DOI:10.3233/jad-220866
摘要

Background: Laboratory investigations have demonstrated that near-infrared (NIR) light treatment can reduce amyloid-β burden in models of Alzheimer’s disease (AD). However, previous clinical studies are rather insufficient. Objective: Before starting a large-scale clinical trial, we performed a pilot study to characterize the efficacy of NIR light for AD patients. Methods: Twenty participants with mild to moderate AD were assigned randomly to the intervention (1060-1080 nm and 800-820 nm NIR light treatment for 12 weeks) or control group (without sham treatment). Safety and efficacy were evaluated at baseline, week 4, 8, and 12, and 4 weeks after treatment. Results: In the intervention and control groups at week 12, mean changes from baseline on the Alzheimer’s Disease Assessment Scale-Cognitive (ADAS-Cog) were -3.1 and -1.3 (p = 0.5689). Mean changes from baseline on the Activities of Daily Living (ADL) were -3.6 versus 3.1 (p = 0.0437). Mean changes from baseline on the Mini-Mental State Examination (MMSE) were 4.4 versus 1.0 (p = 0.0253). The percentage of participants who exhibited a change larger than 4 points from baseline to week 12 was determined for the intervention and control groups on the ADAS-Cog (57% versus 29%), ADL (29% versus 0%), and MMSE (57% versus 14%). Treatment with NIR light did not increase the incidence of adverse events in participants. Conclusion: NIR light treatment appears to be safe and potentially beneficial for AD patients. It improved cognitive function and activities of daily living. The preliminary data encouraged us to launch a large-sample, multicenter, double-blind clinical trial.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ZZICU完成签到,获得积分10
刚刚
1秒前
3秒前
orixero应助YY采纳,获得10
3秒前
开心发布了新的文献求助10
4秒前
4秒前
淡然的钢笔完成签到,获得积分10
5秒前
wanci应助又喝多了采纳,获得10
5秒前
6秒前
Evan完成签到 ,获得积分10
6秒前
今天吃什么完成签到,获得积分10
7秒前
枯木逢春应助伤心猪大肠采纳,获得10
7秒前
yoona发布了新的文献求助10
9秒前
9秒前
禾平发布了新的文献求助10
9秒前
一条热带鱼完成签到,获得积分10
10秒前
sb发布了新的文献求助10
11秒前
11秒前
舒适亦凝发布了新的文献求助10
12秒前
jevon应助刘鑫尧采纳,获得10
12秒前
Orange应助Aries采纳,获得20
12秒前
puyuanting发布了新的文献求助10
12秒前
13秒前
Janel完成签到,获得积分10
13秒前
天天快乐应助刘斌采纳,获得10
14秒前
14秒前
明理嫣发布了新的文献求助10
15秒前
李爱国应助舒适亦凝采纳,获得10
16秒前
pinge发布了新的文献求助10
16秒前
16秒前
连衣裙发布了新的文献求助10
17秒前
木木发布了新的文献求助10
17秒前
fy发布了新的文献求助10
18秒前
斯文败类应助竞鹤采纳,获得10
19秒前
skyrmion发布了新的文献求助10
19秒前
19秒前
微笑涔雨应助51522采纳,获得20
20秒前
VDC应助舒舒采纳,获得30
20秒前
20秒前
20秒前
高分求助中
歯科矯正学 第7版(或第5版) 1004
Semiconductor Process Reliability in Practice 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
GROUP-THEORY AND POLARIZATION ALGEBRA 500
Mesopotamian divination texts : conversing with the gods : sources from the first millennium BCE 500
Days of Transition. The Parsi Death Rituals(2011) 500
The Heath Anthology of American Literature: Early Nineteenth Century 1800 - 1865 Vol. B 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3233417
求助须知:如何正确求助?哪些是违规求助? 2879936
关于积分的说明 8213289
捐赠科研通 2547370
什么是DOI,文献DOI怎么找? 1376892
科研通“疑难数据库(出版商)”最低求助积分说明 647713
邀请新用户注册赠送积分活动 623144