先天性淋巴细胞
生物
祖细胞
诱导多能干细胞
干细胞
免疫学
造血
细胞生物学
人口
先天免疫系统
祖细胞
胚胎干细胞
免疫系统
遗传学
医学
基因
环境卫生
作者
Jiapin Xiong,Yalan Zhao,Yunqing Lin,Chen LeBei,Qitong Weng,Chuanping Shi,Xiaofei Liu,Geng Yang,Lijuan Liu,Jinyong Wang,Mengyun Zhang
出处
期刊:Cell Reports
[Elsevier]
日期:2022-11-01
卷期号:41 (5): 111569-111569
被引量:3
标识
DOI:10.1016/j.celrep.2022.111569
摘要
Innate lymphoid cells (ILCs) play important roles in regulating tissue homeostasis and innate immune responses. Generation of ILCs after engraftment of pluripotent stem cell (PSC)-derived hematopoietic progenitors (iHPCs) has not yet been reported. Here, we document that ILCs exist in Rag2-/-Il2rg-/- recipients engrafted with PSC-derived iHPCs guided by Runx1 and Hoxa9 expression. Upon transplantation, iHPCs immediately give rise to ILC-related progenitors containing common helper ILC progenitors in the bone marrow, followed by a more restricted population named ILC progenitors, which are able to further differentiate into mature ILCs in the primary and secondary immunodeficient recipients. The PSC-derived ILCs exhibit multiple tissue distributions and normal immunological functions. Single-cell transcriptomics illustrates the developmental trajectory of PSC-derived ILCs in vivo, which is consistent with that of natural ILCs. Our study provides insights into the generation of ILCs in animals transplanted with PSC-derived iHPCs as a cell source.
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