Characteristics of exposure to 10 polycyclic aromatic hydrocarbon metabolites among pregnant women: cohort of pregnant women in Zunyi, southwest China

代谢物 尿 多环芳烃 环境化学 化学 生理学 医学 内科学 有机化学
作者
Yingkuan Tian,Renjuan Zhang,Xiang Liu,Yijun Liu,Shimin Xiong,Xia Wang,Haonan Zhang,Quan Li,Juan Liao,Derong Fang,Linglu Wang,Ya Zhang,Hongyu Yuan,Li Zhang,Caidie He,Songlin An,Wei Chen,Yuanzhong Zhou,Xubo Shen
出处
期刊:Occupational and Environmental Medicine [BMJ]
卷期号:80 (1): 34-41 被引量:13
标识
DOI:10.1136/oemed-2022-108324
摘要

Objective Our aim was to elucidate the polycyclic aromatic hydrocarbon (PAH) metabolites exposure levels of pregnant women in the underdeveloped region of Zunyi, southwest China. Methods Sociodemographic information was collected via questionnaires, and urine samples were collected at the same time. A total of 3047 pregnant women participated in the study. Gas chromatography/mass spectrometry was used to detect the urine concentrations of 10 PAH metabolites. A generalised linear model (GLM) was used to identify predictive factors of PAH metabolites. Results All PAH metabolites had a detection rate greater than 60% (67.21%–90.57%) except for 4-OH-PHE at 55.54%. The median concentrations were 0.02–0.11 µg/g Cre except for 1-OH-NAP, 2-OH-NAP, 2-OH-FLU and 9-OH-FLU (0.36–0.50 µg/g Cre). The cluster analysis identified the phenanthrene and fluorene metabolite clusters (containing no other metabolites), while naphthalene metabolites (1-OH-NAP, 2-OH-NAP) could not be clustered without other metabolites. GLM analysis identified that pregnant women with the following characteristics have high urinary concentration of PAH metabolites: overweight, in the last trimester of pregnancy, distance between their house and main traffic lines as <5 m, use fuel for cooking, passive smoking, renovated their residence for less than 3 years, middle family income and office workers. Conclusion The results clarified pregnant women from the economically underdeveloped area could be the victims of PAHs. In addition, PAHs present a demographic and seasonal differential distribution, which will aid in the development of targeted interventions and reduce exposure to PAHs during pregnancy.

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