光敏剂
光动力疗法
癌症研究
转铁蛋白受体
化学
癌细胞
三阴性乳腺癌
肿瘤缺氧
活性氧
铱
受体
癌症
生物
生物化学
医学
乳腺癌
内科学
光化学
催化作用
有机化学
放射治疗
遗传学
作者
Yu‐Yi Ling,Wen‐Jin Wang,Hao Liang,Xiaowen Wu,Junkai Liang,Hang Zhang,Zong‐Wan Mao,Liang‐Nian Ji
出处
期刊:Small
[Wiley]
日期:2022-10-30
卷期号:18 (49)
被引量:29
标识
DOI:10.1002/smll.202203659
摘要
Photoimmunotherapy is attractive for cancer treatment due to its spatial controllability and sustained responses. This work presents a ferrocene-containing Ir(III) photosensitizer (IrFc1) that can bind with transferrin and be transported into triple-negative breast cancer (TNBC) cells via a transferrin receptor-mediated pathway. When the ferrocene in IrFc1 is oxidized by reactive oxygen species, its capability to photosensitize both type I (electron transfer) and type II (energy transfer) pathways is activated through a self-amplifying process. Upon irradiation, IrFc1 induces the generation of lipid oxidation to cause ferroptosis in TNBC cells, which promotes immunogenic cell death (ICD) under both normoxia and hypoxia. In vivo, IrFc1 treatment elicits a CD8+ T-cell response, which activates ICD in TNBC resulting in enhanced anticancer immunity. In summary, this work reports a small molecule-based photosensitizer with enhanced cancer immunotherapeutic properties by eliciting ferroptosis through a self-amplifying process.
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