柚皮素
产热
肠道菌群
脂肪组织
褐变
内分泌学
白色脂肪组织
内科学
脂肪细胞
盲肠
饮食性肥胖
生物
化学
肥胖
生物化学
类黄酮
胰岛素抵抗
医学
抗氧化剂
作者
Sha Zhang,Jinjie Li,Xiasheng Shi,Xiaomeng Tan,Quanjin Si
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:13 (19): 9918-9930
被引量:11
摘要
Naringenin is a kind of natural citrus flavonoid with various biological and pharmacological functions. Several studies have reported the anti-obesity effect of naringenin, but its potential mechanism of action (MoA) on beige adipose browning remains unclear. Here, we investigated whether naringenin induces gut microbe-host interactions to promote beige adipose thermogenesis and browning. Naringenin treatment alleviated obesity, increased body's energy expenditure and activated inguinal white adipose tissue thermogenesis and browning in high fat diet (HFD) fed mice. In addition, naringenin improved HFD-induced gut microbiota dysbiosis and increased short-chain fatty acid (SCFA) levels (especially acetic acid) in a host's cecum and serum. Furthermore, using antibiotic treatment and gut microbe transplantation, we found that gut microbes played an indispensable role in naringenin-induced beige fat browning and naringenin-exerted anti-obesity effects. Our study suggests that naringenin activated beige adipose thermogenesis and browning by gut microbe-SCFA-host interactions, which increase energy expenditure and prevent HFD-induced obesity.
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