Clearance of multiple cutaneous warts by targeting a single lesion: A randomized comparative evaluation of mild local hyperthermia versus cryotherapy

To the Editor: Multiple mucocutaneous warts are common in patients due to virus spreading or self-inoculation, as exemplified by 22.2% of the patients with plantar warts having more than one lesion.1 Specific immune responses against human papillomavirus-harboring lesions contribute to self-regression or treatment-mediated clearance of warts. As such, the treatment-induced immune response to one target lesion could likely initiate the immune-mediated clearance of untargeted or remote lesions in patients with multiple warts containing the same human papillomavirus types.