Health-related heterogeneity in brain aging and associations with longitudinal change in cognitive function

认知 认知功能衰退 医学 潜在类模型 老年学 纵向研究 睡眠剥夺对认知功能的影响 神经影像学 脑老化 心理学 痴呆 精神科 内科学 疾病 病理 统计 数学
作者
Jo Wrigglesworth,Joanne Ryan,Phillip Ward,Robyn L. Woods,Elsdon Storey,Gary Egan,Anne Murray,Sara E. Espinoza,Raj C. Shah,Ruth E Trevaks,Stephanie A. Ward,Ian H. Harding
出处
期刊:Frontiers in Aging Neuroscience [Frontiers Media]
卷期号:14
标识
DOI:10.3389/fnagi.2022.1063721
摘要

Introduction Neuroimaging-based ‘brain age’ can identify individuals with ‘advanced’ or ‘resilient’ brain aging. Brain-predicted age difference (brain-PAD) is predictive of cognitive and physical health outcomes. However, it is unknown how individual health and lifestyle factors may modify the relationship between brain-PAD and future cognitive or functional performance. We aimed to identify health-related subgroups of older individuals with resilient or advanced brain-PAD, and determine if membership in these subgroups is differentially associated with changes in cognition and frailty over three to five years. Methods Brain-PAD was predicted from T1-weighted images acquired from 326 community-dwelling older adults (73.8 ± 3.6 years, 42.3% female), recruited from the larger ASPREE (ASPirin in Reducing Events in the Elderly) trial. Participants were grouped as having resilient (n=159) or advanced (n=167) brain-PAD, and latent class analysis (LCA) was performed using a set of cognitive, lifestyle, and health measures. We examined associations of class membership with longitudinal change in cognitive function and frailty deficit accumulation index (FI) using linear mixed models adjusted for age, sex and education. Results Subgroups of resilient and advanced brain aging were comparable in all characteristics before LCA. Two typically similar latent classes were identified for both subgroups of brain agers: class 1 were characterized by low prevalence of obesity and better physical health and class 2 by poor cardiometabolic, physical and cognitive health. Among resilient brain agers, class 1 was associated with a decrease in cognition, and class 2 with an increase over 5 years, though was a small effect that was equivalent to a 0.04 standard deviation difference per year. No significant class distinctions were evident with FI. For advanced brain agers, there was no evidence of an association between class membership and changes in cognition or FI. Conclusion These results demonstrate that the relationship between brain age and cognitive trajectories may be influenced by other health-related factors. In particular, people with age-resilient brains had different trajectories of cognitive change depending on their cognitive and physical health status at baseline. Future predictive models of aging outcomes will likely be aided by considering the mediating or synergistic influence of multiple lifestyle and health indices alongside brain age.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xzy998应助科研通管家采纳,获得10
刚刚
斯文败类应助科研通管家采纳,获得10
刚刚
天天快乐应助科研通管家采纳,获得10
刚刚
GB发布了新的文献求助30
刚刚
夜曦完成签到 ,获得积分0
2秒前
DELI完成签到 ,获得积分10
4秒前
白智妍完成签到,获得积分10
4秒前
4秒前
5秒前
Snail发布了新的文献求助10
9秒前
俭朴的世界完成签到 ,获得积分10
9秒前
十七完成签到 ,获得积分10
10秒前
李梦媛完成签到 ,获得积分10
10秒前
小七完成签到,获得积分10
11秒前
leapper完成签到 ,获得积分10
11秒前
光亮的绮晴完成签到 ,获得积分10
11秒前
赘婿应助大橙子采纳,获得10
17秒前
sfsfes应助ABC采纳,获得10
17秒前
SciGPT应助强公子采纳,获得10
17秒前
RXY完成签到,获得积分10
18秒前
量子星尘发布了新的文献求助10
20秒前
明明完成签到,获得积分10
21秒前
求知的周完成签到,获得积分10
21秒前
22秒前
柒柒球完成签到,获得积分10
22秒前
赵田完成签到 ,获得积分10
23秒前
23秒前
长安完成签到,获得积分10
27秒前
大橙子发布了新的文献求助10
28秒前
在水一方应助Herisland采纳,获得10
30秒前
笨笨小刺猬完成签到,获得积分10
32秒前
32秒前
科研小达人完成签到,获得积分10
35秒前
追寻凌青完成签到,获得积分10
37秒前
渡劫完成签到,获得积分10
38秒前
丫丫完成签到 ,获得积分10
38秒前
lxy发布了新的文献求助10
39秒前
bono完成签到 ,获得积分10
42秒前
DentistRui完成签到,获得积分10
42秒前
44秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022