生物降解
明胶
降级(电信)
动力学
聚合物
凝聚
化学工程
化学
材料科学
可生物降解聚合物
分解
核磁共振波谱
色谱法
有机化学
电信
物理
工程类
量子力学
计算机科学
作者
Uyen Thi,Jiwon Kim,Quy Son Luu,Quynh Thi Nguyen,Tae Ho Jang,Yeeun Park,Hwicheol Shin,Nicholas Whiting,Dong‐Ku Kang,Jae‐Sung Kwon,Youngbok Lee
标识
DOI:10.1016/j.carbpol.2022.120490
摘要
With an increase in the severity of environmental pollution caused by microbeads, the development of biodegradable microcapsules that can be applied in diverse fields has attracted significant attention. The degradation processes are directly related to biodegradable microcapsule creation with high stability and persistence. In this study, biodegradable microcapsules are synthesized via a complex coacervation approach using gelatin and alginate as the capsule main wall materials; additionally, enzyme-induced decomposition mechanisms are proposed by observing spectral changes in proton nuclear magnetic resonance (1H NMR) analyses. Additional analytical techniques confirm the chemical structure, morphology, and size distribution of the synthesized capsules; these uniform spherical microcapsules are 20-30 μm in size and possess a smooth surface. In addition to characterization, the microcapsules were exposed to targeted enzymes to investigate enzymatic effects using short-term and long-term degradation kinetics. Close inspection reveals that determination of the degradation rate constant of the major components in the capsule is feasible, and suggests two types of 4-stage degradation mechanisms that are enzyme-specific. These investigations demonstrate that capsule degradation can be explored in detail using 1H NMR spectroscopy to provide a viable strategy for monitoring degradation properties in the development of new biodegradable polymers.
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