化学
弹性蛋白酶
癌症研究
蛋白酵素
中性粒细胞弹性蛋白酶
肿瘤微环境
病理生理学
蛋白酶
生物化学
肿瘤细胞
酶
病理
医学
免疫学
炎症
作者
Weilin Zeng,Yingqiu Song,Runze Wang,Rong He,Tianlu Wang
标识
DOI:10.1016/j.jpha.2022.12.003
摘要
Neutrophil elastase (NE), a major protease in the primary granules of neutrophils, is involved in microbicidal activity. NE is an important factor promoting inflammation, has bactericidal effects, and shortens the inflammatory process. NE also regulates tumor growth by promoting metastasis and tumor microenvironment remodeling. However, NE plays a role in killing tumors under certain conditions and promotes other diseases such as pulmonary ventilation dysfunction. Additionally, it plays a complex role in various physiological processes and mediates several diseases. Sivelestat, a specific NE inhibitor, has strong potential for clinical application, particularly in the treatment of coronavirus disease 2019 (COVID-19). This review discusses the pathophysiological processes associated with NE and the potential clinical applications of sivelestat.
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