背景(考古学)
癌症
程序性细胞死亡
细胞凋亡
胃肠道
机制(生物学)
医学
胃肠道癌
癌症研究
生物
结直肠癌
内科学
遗传学
古生物学
哲学
认识论
作者
Ruoxi Zhang,Rui Kang,Daolin Tang
出处
期刊:Cancer Letters
[Elsevier]
日期:2023-05-01
卷期号:561: 216147-216147
被引量:20
标识
DOI:10.1016/j.canlet.2023.216147
摘要
Ferroptosis is a form of regulated cell death that is initiated by excessive lipid peroxidation that results in plasma membrane damage and the release of damage-associated molecular patterns. In recent years, ferroptosis has gained significant attention in cancer research due to its unique mechanism compared to other forms of regulated cell death, especially caspase-dependent apoptotic cell death. Gastrointestinal (GI) cancer encompasses malignancies that arise in the digestive tract, including the stomach, intestines, pancreas, colon, liver, rectum, anus, and biliary system. These cancers are a global health concern, with high incidence and mortality rates. Despite advances in medical treatments, drug resistance caused by defects in apoptotic pathways remains a persistent challenge in the management of GI cancer. Hence, exploring the role of ferroptosis in GI cancers may lead to more efficacious treatment strategies. In this review, we provide a comprehensive overview of the core mechanism of ferroptosis and discuss its function, regulation, and implications in the context of GI cancers.
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