创伤性脑损伤
淋巴系统
淋巴系统
医学
海马体
脑脊液
神经保护
间质液
病理
皮质(解剖学)
麻醉
神经科学
药理学
内科学
生物
精神科
作者
Mingqi Liu,Jinhao Huang,Tao Liu,Jiangyuan Yuan,Chuanxiang Lv,Zhuang Sha,Chenrui Wu,Weiwei Jiang,Xuanhui Liu,Meng Nie,Yu-Peng Chen,Shiying Dong,Qian Yu,Chuang Gao,Yanni Fan,Di Wu,Rongcai Jiang
标识
DOI:10.1186/s40478-023-01555-4
摘要
Abstract The persistent dysregulation and accumulation of poisonous proteins from destructive neural tissues and cells activate pathological mechanisms after traumatic brain injury (TBI). The lymphatic drainage system of the brain, composed of the glymphatic system and meningeal lymphatic vessels (MLVs), plays an essential role in the clearance of toxic waste after brain injury. The neuroprotective effect of interleukin 33 (IL-33) in TBI mice has been demonstrated; however, its impact on brain lymphatic drainage is unclear. Here, we established a fluid percussion injury model to examine the IL-33 administration effects on neurological function and lymphatic drainage in the acute brain of TBI mice. We verified that exogenous IL-33 could improve the motor and memory skills of TBI mice and demonstrated that in the acute phase, it increased the exchange of cerebrospinal and interstitial fluid, reversed the dysregulation and depolarization of aquaporin-4 in the cortex and hippocampus, improved the drainage of MLVs to deep cervical lymph nodes, and reduced tau accumulation and glial activation. We speculate that the protective effect of exogenous IL-33 on TBI mice’s motor and cognitive functions is related to the enhancement of brain lymphatic drainage and toxic metabolite clearance from the cortex and hippocampus in the acute stage. These data further support the notion that IL-33 therapy may be an effective treatment strategy for alleviating acute brain injury after TBI.
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