齐墩果酸
三萜类
化学
立体化学
IC50型
二维核磁共振波谱
薯蓣
生物化学
体外
生物
植物
医学
替代医学
病理
作者
Lan Huang,Ziqi Wang,Fangxin Wang,Song Wang,Dezhi Wang,Meihua Gao,Hua Li,Min Song,Xiao‐Qi Zhang
出处
期刊:Molecules
[MDPI AG]
日期:2024-04-05
卷期号:29 (7): 1640-1640
被引量:1
标识
DOI:10.3390/molecules29071640
摘要
Six new 2α-hydroxy ursane triterpenoids, 3α-cis-p-coumaroyloxy-2α,19α-dihydroxy-12-ursen-28-oic acid (1), 3α-trans-p-coumaroyloxy-2α,19α-dihydroxy-12-ursen-28-oic acid (2), 3α-trans-p-coumaroyloxy-2α-hydroxy-12-ursen-28-oic acid (3), 3β-trans-p-coumaroyloxy-2α-hydroxy-12,20(30)-ursadien-28-oic acid (4), 3β-trans-feruloyloxy-2α-hydroxy-12,20(30)-ursadien-28-oic acid (5), and 3α-trans-feruloyloxy-2α-hydroxy-12,20(30)-ursadien-28-oic acid (6), along with eleven known triterpenoids (7–17), were isolated from the leaves of Diospyros digyna. Their chemical structures were elucidated by comprehensive analysis of UV, IR, HRESIMS, and NMR spectra. All the isolated compounds were evaluated for their PTP1B inhibitory activity. 3β-O-trans-feruloyl-2α-hydroxy-urs-12-en-28-oic acid (13) showed the best inhibition activity with an IC50 value of 10.32 ± 1.21 μM. The molecular docking study found that the binding affinity of compound 13 for PTP1B was comparable to that of oleanolic acid (positive control).
科研通智能强力驱动
Strongly Powered by AbleSci AI