化学
铱
对映选择合成
催化作用
表面改性
组合化学
光催化
磷酸
有机化学
光催化
物理化学
作者
Xiaohu Deng,Feng Jiang,Xiaoming Wang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-03-15
卷期号:26 (12): 2483-2488
被引量:1
标识
DOI:10.1021/acs.orglett.4c00692
摘要
An enantioselective deoxygenative functionalization of secondary amides with vinylpridines is developed by merging relay iridium catalysis and cooperative photoredox-chiral Brønsted acid catalysis, affording a series of valuable chiral amines in moderate to good yields with good enantioselectivities. The intriguing multiple catalytic system invoking triple-catalysis was found to be the key to the success of the current reactions, which may stimulate further development of catalytic methodologies for asymmetric deoxygenative transformations of amides.
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