胶束
葡萄糖氧化酶
材料科学
催化作用
肿瘤微环境
化学
纳米技术
组合化学
生物物理学
生物传感器
免疫系统
生物
有机化学
生物化学
水溶液
免疫学
作者
Qianqian Lu,Mengmeng Hou,Xirui Huang,Hongyue Yu,Xingjin Li,Jia Jia,Qiaoyu Zhou,Kexin Lv,Tingting Ren,Minchao Liu,Yating Zhan,Yufang Kou,Lingkai Dong,Tiancong Zhao,Xiaomin Li
标识
DOI:10.1002/adfm.202401328
摘要
Abstract The catalytic therapy based on the nanozymes has received increasing interest in cancer treatment. However, the catalytic capabilities of standalone nanozymes are relatively limited, necessitating the development of a nano‐bio composite system that integrates both nanozymes and natural enzymes. This construction often inevitably leads to interference between natural enzyme and nanozymes, resulting in reduced synergistic performance. Herein, a cascade catalysis system featuring the “core@paratroopers” structure is proposed, wherein hollow manganese dioxide (HMnO 2 ) serves as “core” and ultra‐small hybrid single‐micelle (H‐micelle) encapsulated with glucose oxidase (GOx) as “paratroopers” (H‐micelle‐GOx). The outer SiO 2 layer of the H‐micelle can effectively protect the GOx. Under hypoxic conditions, HMnO 2 reacts with endogenous H 2 O 2 to produce O 2 , thereby enhancing the catalytic efficiency of GOx for starvation therapy. Simultaneously, the generated H 2 O 2 boosts the catalytic efficiency of HMnO 2 , accelerating local O 2 generation and alleviating tumor hypoxia. Additionally, this system exhibits rapid degradation in the tumor microenvironment characterized by high glutathione (GSH) expression, facilitating the release and deep penetration of the ultra‐small H‐micelle‐GOx “paratroopers” within the solid tumor.
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