Sex differences in osteosarcoma survival across the age spectrum: A National Cancer Database analysis (2004–2016)

医学 危险系数 比例危险模型 置信区间 骨肉瘤 人口学 生存分析 入射(几何) 癌症 内科学 年轻人 数据库 病理 社会学 计算机科学 物理 光学
作者
Lindsay A. Williams,Sofia Barragan,Zhanni Lu,Brenda Weigel,Logan G. Spector
出处
期刊:Cancer Epidemiology [Elsevier]
卷期号:: 102565-102565
标识
DOI:10.1016/j.canep.2024.102565
摘要

Osteosarcoma displays a bimodal peak in incidence in adolescence and later adulthood. Males are more frequently diagnosed with osteosarcoma in both periods. Males have worse survival than females, which is generally poor at 30–70% 5-years post diagnosis, depending on age, but treatment received is often unaccounted for in survival analyses. Therefore, we estimated sex differences in survival for children and adults stratifying by treatment received and other disease characteristics using the National Cancer Database (2004–2016, n=9017). We estimated sex differences in long-term survival using Kaplan Meier survival curves and Log-Rank p-values. We also estimated hazard ratios (HR) and 95% confidence intervals (CIs) as the measure of association between sex and death using Cox regression. In all age groups, cases were predominantly male (52–58%). In Kaplan-Meier analyses, males had worse overall survival than females for 0–19, 20–39, and ≥60-year-olds (Log-Rank p<0.05). Females had higher 5- and 10-year survival percentages in all age groups. In adjusted Cox models, males had a higher risk of death among 0–19-year-olds (HRoverall: 1.24, 95% CI: 1.06–1.44; HRnon-metastatic disease: 1.35, 95% CI: 1.12, 1.63, HRlower limb tumors: 1.31, 95% CI: 1.09–1.59). Among 20–39-year-olds, males had an increased risk of death when receiving surgery only (HR: 4.67, 95% CI: 1.44, 15.09). Among those ≥60-year-olds, males had a suggestive increased risk of death overall (HR: 1.17, 95% CI: 0.99–1.39) and a higher risk of death based on some tumor locations, (HRupper limb: 2.52, 95% CI: 1.24, 5.11; HRmidline: 1.36, 95% CI: 1.02, 1.82). Our findings suggest that the worse survival among young males compared to females with osteosarcoma persisted after accounting for many major disease characteristics, including treatment received. Collectively, our work points toward other unexplored mechanisms beyond treatment, potentially biologic or otherwise, which may be driving the observed sex differences in long-term survival.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
Aixia完成签到 ,获得积分10
1秒前
葡萄糖完成签到,获得积分10
1秒前
哈哈完成签到,获得积分10
1秒前
在水一方应助CC采纳,获得10
1秒前
1秒前
余笙完成签到 ,获得积分10
2秒前
神勇的雅香应助科研混子采纳,获得10
2秒前
TT发布了新的文献求助10
3秒前
李顺完成签到,获得积分20
4秒前
ayin发布了新的文献求助10
4秒前
wait发布了新的文献求助10
4秒前
我是站长才怪应助xg采纳,获得10
5秒前
童话艺术佳完成签到,获得积分10
5秒前
稀罕你完成签到,获得积分10
5秒前
junzilan发布了新的文献求助10
5秒前
anny.white完成签到,获得积分10
6秒前
科研通AI5应助平常的毛豆采纳,获得10
8秒前
SciGPT应助paul采纳,获得10
11秒前
13秒前
英姑应助书生采纳,获得10
14秒前
科研钓鱼佬完成签到,获得积分10
15秒前
17秒前
petrichor应助C_Cppp采纳,获得10
17秒前
nan完成签到,获得积分10
17秒前
17秒前
18秒前
18秒前
勤恳的雨文完成签到,获得积分10
18秒前
木森ab发布了新的文献求助10
19秒前
paul完成签到,获得积分10
19秒前
小鞋完成签到,获得积分10
20秒前
开心青旋发布了新的文献求助10
20秒前
fztnh发布了新的文献求助10
20秒前
无名花生完成签到 ,获得积分10
20秒前
22秒前
23秒前
23秒前
杜若完成签到,获得积分10
23秒前
23秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Social media impact on athlete mental health: #RealityCheck 1020
Ensartinib (Ensacove) for Non-Small Cell Lung Cancer 1000
Unseen Mendieta: The Unpublished Works of Ana Mendieta 1000
Bacterial collagenases and their clinical applications 800
El viaje de una vida: Memorias de María Lecea 800
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3527990
求助须知:如何正确求助?哪些是违规求助? 3108173
关于积分的说明 9287913
捐赠科研通 2805882
什么是DOI,文献DOI怎么找? 1540119
邀请新用户注册赠送积分活动 716941
科研通“疑难数据库(出版商)”最低求助积分说明 709824