医学
后代
怀孕
遗传变异
遗传诊断
产科
遗传学
生物
基因型
基因
作者
Amit Srivastava,Nagendra Monangi,Vidhya Ravichandran,Pol Solé-Navais,Bo Jacobsson,Louis J. Muglia,Stefan Johansson
标识
DOI:10.1016/j.clp.2024.02.010
摘要
Preterm birth (PTB) is the leading cause of infant mortality and morbidity. For several decades, extensive epidemiologic and genetic studies have highlighted the significant contribution of maternal and offspring genetic factors to PTB. This review discusses the challenges inherent in conventional genomic analyses of PTB and underscores the importance of adopting nonconventional approaches, such as analyzing the mother–child pair as a single analytical unit, to disentangle the intertwined maternal and fetal genetic influences. We elaborate on studies investigating PTB phenotypes through 3 levels of genetic analyses: single-variant, multivariant, and genome-wide variants.
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