In this Letter, we propose an in-line tilted fiber Bragg grating sensor for temperature and strain measurements. The grating is inscribed in a specialty optical fiber using tightly focused femtosecond laser pulses and the line-by-line direct writing method. Beside the central core in which the grating is produced, a hollow channel filled with glycerol aqueous solution significantly improves the sensitivity of the fiber cladding modes due to its high thermo-optic coefficient. We show that the temperature sensitivity of the core mode is 9.8 pm/°C, while the one of the cladding modes is strongly altered and can reach −24.3 pm/°C, in the investigated range of 20–40°C. For the strain measurement, sensitivities of the core mode and the cladding modes are similar (∼0.60 pm/με) between 0 and 2400 με. The significative difference of temperature sensitivity between the two modes facilitates the discrimination of the dual parameters in simultaneous measurements.