A novel microwave dielectric ceramic of SrGa2Si2O8 was synthesized using the traditional solid-state method. Its phase composition, microstructure, and microwave dielectric properties were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Raman spectroscopy, and network analyzer. XRD results indicated that the space group of the ceramic transformed from I2/c to P21/a at 700 °C. A combination of good microwave dielectric properties was obtained at 1260 °C with εr = 6.3, Q×f= 96,600 GHz and τf = −45.2 ppm/°C at 16.5 GHz. The negative τf can be tuned to near zero by adding 15 mol% CaTiO3. The densification temperature can be reduced to 940 °C by adding 4 wt% LiF. Moreover, the SrGa2Si2O8 ceramic had good chemical compatibility with the Ag electrode. A patch antenna was designed using the 0.85SrGa2Si2O8 + 0.15CaTiO3 + 4 wt% LiF ceramic. The antenna had a high radiation efficiency of 99.2 % and a gain of 2.988 dBi at the center frequency of 4.261 GHz. All results indicated that the SrGa2Si2O8 ceramic has promising potential for applications in 5 G wireless communication technology.