剪接体
生物
内含子
RNA剪接
前列腺癌
基因
遗传学
癌症研究
癌症
核糖核酸
作者
Jonàs Juan‐Mateu,Juan Valcárcel
标识
DOI:10.1016/j.molcel.2023.05.027
摘要
The minor spliceosome regulates the removal of a conserved subset of introns present in genes with regulatory functions. In this issue of Molecular Cell, Augspach et al. 1 Augspach A. Drake K.D. Roma L. Qian E. Lee S.R. Clarke D. Kumar S. Jaquet M. Gallon J. Bolis M. et al. Minor intron splicing is critical for survival of lethal prostate cancer. Mol. Cell. 2023; 83: 1983-2002 Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar report that elevated levels of U6atac snRNA, a key minor spliceosome component, contribute to prostate cancer cell growth and can be a novel therapeutic target. The minor spliceosome regulates the removal of a conserved subset of introns present in genes with regulatory functions. In this issue of Molecular Cell, Augspach et al. 1 Augspach A. Drake K.D. Roma L. Qian E. Lee S.R. Clarke D. Kumar S. Jaquet M. Gallon J. Bolis M. et al. Minor intron splicing is critical for survival of lethal prostate cancer. Mol. Cell. 2023; 83: 1983-2002 Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar report that elevated levels of U6atac snRNA, a key minor spliceosome component, contribute to prostate cancer cell growth and can be a novel therapeutic target. Minor intron splicing is critical for survival of lethal prostate cancerAugspach et al.Molecular CellJune 8, 2023In BriefAugspach et al. discover a significant vulnerability in therapy-resistant prostate cancer. They show that RNAi-based inhibition of the minor spliceosome blocked the cell cycle and reduced survival in cancer cells, whereas it did not affect non-cancer cells. This approach was more effective than current state-of-the-art therapies. Full-Text PDF
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