痴呆
脑电图
血管性痴呆
疾病
阿尔茨海默病
人口
听力学
神经科学
心理学
医学
路易体
认知障碍
路易氏体型失智症
心脏病学
内科学
环境卫生
作者
I. Bèjia,Jordan Labidi,Aude Warniez,Madli Bayot,Jean‐Louis Bourriez,Philippe Derambure,Thibaut Lebouvier,Florence Pasquier,Arnaud Delval,Nacim Betrouni
标识
DOI:10.1016/j.neurobiolaging.2023.06.008
摘要
Electroencephalography’s (EEG) sensitivity in discriminating dementia syndromes remains unclear. This study aimed to investigate EEG markers in patients with major cognitive disorders. The studied population included 4 groups of patients: Alzheimer's disease with associated vascular lesions, Alzheimer’s disease without vascular lesions (AD-V), Lewy body disease and vascular dementia (VaD); and completed by a control group composed by cognitively unimpaired patients. EEGs were analysed quantitatively using spectral analysis, functional connectivity and micro-states. By comparison to the controls, expected slowing and alterations of functional connectivity were detected in patients with dementia. Among these patients, an overall increase in power in the alpha band was observed in the VaD group, mainly when compared to the 2 AD groups, while the Alzheimer’s disease without vascular lesions group exhibited increased power in the beta-2 band and higher functional connectivity in the same frequency band. Micro-state analyses revealed differences in temporal dynamics for the VaD group. A number of EEG modifications reported as markers of some syndromes were found, but others were not reproduced.
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