密封剂
止血
自愈水凝胶
止血剂
伤口愈合
纤维蛋白
明胶
体内
生物医学工程
材料科学
离体
金黄色葡萄球菌
医学
外科
化学
高分子化学
复合材料
免疫学
生物技术
细菌
生物化学
遗传学
生物
作者
Reihaneh Haghniaz,Hossein Montazerian,Atiya Rabbani,Avijit Baidya,Brent Usui,Yangzhi Zhu,Maryam Tavafoghi,Fazli Wahid,Han‐Jun Kim,Amir Sheikhi,Ali Khademhosseini
标识
DOI:10.1002/adhm.202301551
摘要
Abstract Hemorrhage and bacterial infections are major hurdles in the management of life‐threatening surgical wounds. Most bioadhesives for wound closure lack sufficient hemostatic and antibacterial properties. Furthermore, they suffer from weak sealing efficacy, particularly for stretchable organs, such as the lung and bladder. Accordingly, there is an unmet need for mechanically robust hemostatic sealants with simultaneous antibacterial effects. Here, an injectable, photocrosslinkable, and stretchable hydrogel sealant based on gelatin methacryloyl (GelMA), supplemented with antibacterial zinc ferrite (ZF) nanoparticles and hemostatic silicate nanoplatelets (SNs) for rapid blood coagulation is nanoengineered. The hydrogel reduces the in vitro viability of Staphylococcus aureus by more than 90%. The addition of SNs (2% w/v) and ZF nanoparticles (1.5 mg mL −1 ) to GelMA (20% w/v) improves the burst pressure of perforated ex vivo porcine lungs by more than 40%. Such enhancement translated to ≈250% improvement in the tissue sealing capability compared with a commercial hemostatic sealant, Evicel. Furthermore, the hydrogels reduce bleeding by ≈50% in rat bleeding models. The nanoengineered hydrogel may open new translational opportunities for the effective sealing of complex wounds that require mechanical flexibility, infection management, and hemostasis.
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