材料科学
石墨烯
纳米技术
化学气相沉积
光电子学
生物传感器
电极
检出限
微电子
数学
统计
物理化学
化学
作者
Cuicui Li,Yilun Cai,Jinrong Hu,Jiawei Liu,Honglian Dai,Qingfang Xu,Ji Shi,Xian Zhang,Kai Liu,М. Л. Косинова,Takashi Goto,Rong Tu,Song Zhang
标识
DOI:10.1021/acsami.3c04628
摘要
Implantable electrochemical sensor holds great promise in the real-time monitoring of dopamine (DA) to regulate body function. However, the real application of these sensors is limited by the weak current signal of DA in the human body and the poor compatibility of the on-chip microelectronic devices. In this work, a SiC/graphene composite film was fabricated using laser chemical vapor deposition (LCVD) and employed as a DA sensor. The graphene in the porous nanoforest-like SiC framework offered efficient channels for electronic transmission, leading to an enhanced electron transfer rate and consequently an increased current response for DA detection. The three-dimensional (3D) porous network also facilitated the exposure of more catalytic active sites toward DA oxidation. Besides, the wide distribution of graphene in the nanoforest-like SiC films reduced the interfacial resistance of the charge transfer. The SiC/graphene composite film exhibited excellent electrocatalytic activity toward DA oxidation with a low detection limit of 0.11 μM and a high sensitivity of 0.86 μA·μM-1·cm-2. The film electrode also showed a wide linear response for DA in 0.5-78 μM, along with good selectivity, repeatability, and reproducibility. Furthermore, the cell counting kit-8 (CCK-8) and live-dead assays revealed that the film is also biocompatible for biomedical applications. Therefore, the nanoforest-like SiC/graphene composite film via the CVD process enables a promising candidate for an integrated miniature DA biosensor with high detection performance.
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