沸石咪唑盐骨架
咪唑酯
自愈水凝胶
药物输送
纳米材料
化学工程
核化学
壳聚糖
生物相容性
化学
纳米技术
材料科学
纳米复合材料
金属有机骨架
高分子化学
有机化学
吸附
工程类
作者
Pagasukon Mekrattanachai,Naruemon Setthaya,Chakkresit Chindawong,Bunlawee Yotnoi,Wei Song,Natchanon Ratanapun,Supreeda Tambunlertchai,Chawan Manaspon
出处
期刊:Journal of Biomimetics, Biomaterials and Biomedical Engineering
日期:2023-05-31
卷期号:60: 29-42
摘要
Zeolitic imidazolate frameworks-8 (ZIF-8), a type of metal-organic frameworks (MOFs), displays high porosity, large surface areas, and tunable functionality in nanocomposites, promising carrier for drug delivery applications. In this work, ZIF-8 nanomaterials were synthesized via precipitation under three different conditions and subsequently loaded onto chitosan/pluronic F-127 (CS/PL) hydrogels. The ZIF-8 materials prepared in NH 4 OH solution (ZIF-8-NH 4 OH) showed a regular cubic shape with a large particle size of approximately 963 nm due to the acceleration of crystal growth in a basic medium. Meanwhile, the ZIF-8 species prepared in H 2 O and MeOH (ZIF-8-H 2 O and ZIF-8-MeOH, respectively) displayed crystal sizes of approximately 152 and 240 nm, respectively. The overall toxicity of the ZIF-8 nanomaterials was determined with an XTT assay against the L929 mouse fibroblast cell line. The morphology of the cells was altered at a concentration of over 30 µg/mL due to cell membrane deformations. This result correlated with the lactate dehydrogenase (LDH) release study by detection of LDH release at a concentration of over 25 µg/mL (50% LDH release). To reduce the toxicity of the ZIF-8 materials, CS/PL hydrogels were appropriately prepared and used to encapsulate the ZIF-8 at 0.095% w/w. Cytotoxicity results of the ZIF-8-loaded CS/PL hydrogels indicated over 75% cell viability of the L929 cells. These results presented significant implications for future applications of the ZIF-8 particles in the delivery of drugs or other compounds.
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