促炎细胞因子
慢性前列腺炎/慢性盆腔疼痛综合征
活性氧
地塞米松
医学
下调和上调
脂多糖
植物化学
盆腔疼痛
糖皮质激素
药理学
前列腺
炎症
化学
前列腺炎
内科学
传统医学
外科
生物化学
癌症
基因
作者
Yang Yang,Ruimin Hu,Jun Zheng,Qianmei Wang,Senlin Xu,Zhansong Zhou,Dinglin Zhang,Wenhao Shen
标识
DOI:10.1186/s12951-023-01893-4
摘要
Abstract Background Chronic pelvic pain syndrome (CPPS) is a typical symptom of chronic prostatitis (CP) in males that may cause abnormal urination, sexual dysfunction, or depression and significantly affect the quality of life of the patient. Currently, there is no effective treatment for CPPS due to its recurrence and intractability. For synergistic CPPS therapy, we developed pH/reactive oxygen species (ROS) dual-responsive dexamethasone (Dex) nanoformulations using a ROS-responsive moiety and phytochemical modified α-cyclodextrin (α-CD) as the carrier. Results Dex release from the nanoformulations can be controlled in acidic and/or ROS-rich microenvironments. The fabricated Dex nanoformulations can also be efficiently internalized by lipopolysaccharide (LPS)-stimulated macrophages, prostatic epithelial cells, and stromal cells. Moreover, the levels of proinflammatory factors (e.g., TNF-α, IL-1β, and IL-17 A) in these cells were significantly decreased by Dex nanoformulations treatment through the release of Dex, phytochemical and elimination of ROS. In vivo experiments demonstrated notable accumulation of the Dex nanoformulations in prostate tissue to alleviate the symptoms of CPPS through the downregulation of proinflammatory factors. Interestingly, depression in mice may be relieved due to alleviation of their pelvic pain. Conclusion We fabricated Dex nanoformulations for the effective management of CPPS and alleviation of depression in mice.
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